陳全姣,博士,學科組長研究員。1997年、2003年于華中農業大學動物醫學學院分別獲得學士及碩士學位,2007年于中國科學院武漢病毒研究所獲博士學位。主要研究方向為自然感染狀態下流感病毒的生物學特征;流感病毒感染致病機制、致死宿主細胞途徑及分子細節;Nipah病毒致病機理。主持項目(課題)包括科技部“973”項目子課題,國家科技重大專項,國家自然科學基金面上和青年基金,多項企業產品體內和體外抗流感病毒藥效評價課題等。在Cell Host & Microbe, Nat Commun,Sci Bull,Clin Infect Dis, mBio,J Virol, Emerg Microbes Infect和Front Microbiol等國際學術期刊發表代表性第一或通訊作者論文。
1. Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway. Gui R, Zheng H, Ma L, Liu R, Lin X, Ke X, Ye C, Jian X, Chen Q. mBio. 2022 Jun 28;13(3):e0061522.
2. G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2. Zheng H, Ma L, Gui R, Lin X, Ke X, Jian X, Ye C, Chen Q. J Virol. 2022 Jun 22;96(12):e0049422.
3. Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19. Lin X, Ke X, Jian X, Xia L, Yang Y, Zhang T, Xiong H, Zhao B, Liu W, Chen Q, Tang C. Sci Bull (Beijing). 2022 May 30;67(10):1022-1025.
4. Emerging highly pathogenic avian influenza (H5N8) virus in migratory birds in Central China, 2020. Xiong J, Zhou H, Fan L, Zhu G, Li Y, Chen G, Zhang J, Li J, Zheng H, Feng W, Chen J, Yang G, Chen Q. Emerg Microbes Infect. 2021 Jul 14:1-35.
5. Dominant subtype switch in avian influenza viruses during 2016-2019 in China. Nat Commun. 2020 Nov 20;11(1):5909
6. Direct evidence of active SARS-CoV-2 replication in the intestine. Clin Infect Dis. 2020 Jul 8:ciaa925.
7. Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. Emerg Microbes Infect. 2018 Feb 7;7(1):14.
8. First documented case of avian influenza (H5N1) virus infection in a lion. Emerg Microbes Infect. 2016 Dec 21;5(12):e125.
9. Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China. Cell Host Microbe. 2016 Dec 14;20(6):810-821.
10. Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice. J Virol. 2015 Dec 9;90(4):2142-9.
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